![]() ![]() By incorporating patient-specific cells, genetic information, and utilizing artificial intelligence (AI) algorithms, scientists hope to create personalized models capable of predicting an individual's response to specific treatments or therapies. This innovative leap aims to replicate the complexity of an individual patient's physiology within a single integrated system. ![]() Researchers are now embarking on a transition from organ-on-a-chip to an even more ambitious concept known as patient-on-a-chip. By mimicking organ interactions, this platform offered a more accurate environment for drug testing and disease modeling, laying the foundation for future biomedical research. By combining multiple organ-on-a-chip models, such as the lung, heart, liver, and blood-brain barrier, this groundbreaking system provided a comprehensive representation of human organ systems. In 2012 researchers from Harvard University's Wyss Institute unveiled an innovative "human-on-a-chip" platform. Through these joint efforts, scientists achieved significant milestones in replicating organ-level functions and understanding how different organs interact on these tiny systems. This collaborative initiative brought together experts from various fields, including biology, engineering, and materials science, to accelerate the development of organ-on-a-chip models for drug discovery and toxicity testing. Since 2012, the program has been led and managed by the National Center for Advancing Translational Sciences (NCATS). The National Institutes of Health's Tissue Chip for Drug Screening program began in 2010 as a five-year partnership among NIH, the Defense Advanced Research Projects Agency (DARPA) and the U.S. By using specialized techniques, researchers successfully developed miniature models of organs, opening up new possibilities for studying human physiology in the lab. ![]() Ingber at Harvard University, this innovative approach aimed to recreate the complex structure and functions of human organs within laboratory settings. Nearly two decades ago, a groundbreaking discovery in the field of biomedical research emerged, known as organ-on-a-chip technology, which quickly captivated the interest of scientists across the globe. ![]()
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